Helen Pensanti MD began her career in traditional gynecology. In her 4th year of private practice, she became alarmed at the serious side effects that her patients experienced from synthetic hormones.
Dr. Pensanti refused to write another prescription for synthetic hormones, and she diligently searched for an alternative. Then, Dr. Pensanti’s weekly national television show "Doctor to Doctor" booked guest John R. Lee MD. When Dr. Pensanti met Dr. Lee, he became her mentor and friend. "It was as if Dr. Lee handed me a baton and said, ‘Now run with it Helen, it's your turn.’"
"What Your Doctor Hasn't Told You About Menopause," Dr. Lee’s best-selling book, mentions Dr. Pensanti. She learned everything she could from Dr. Lee about phyto-progesterone and began treating her patients with it. Eventually, she began manufacturing her own phyto-hormones in 1994.
"The biggest difference between my cremes and other phyto-progesterone cremes is that I refused to put Black Cohosh and Dong Quai into the formula. Black Cohosh and Dong Quai are estrogens, and mixing them with the plant progesterone would cause some women to have two periods a month. As a trained physician in female physiology, I knew that combination would not work."
Dr. Pensanti spoke out against synthetic hormones on “Doctor To Doctor.” Her voice went out across America to explain that synthetic hormones were dangerous and that they could cause breast cancer, stroke, and heart disease. These synthetic hormones were at the time the standard of care for the treatment of PMS, Perimenopause, Menopause, and Osteoporosis. Dr. Pensanti became an "activist" against synthetic hormones.
On July 9, 2002, when The National Institutes of Health stopped the study of women on synthetic Estrogen and synthetic Progestin, Dr. Helen was vindicated. The Institutes concluded that a combination of these drugs demonstrated a 29% increased risk of Breast Cancer, 26% increased risk of a first-time heart attack, 41% increased risk of strokes, and double the risk of blood clots to the legs and lungs.